Mechanisms of HIV Drug Resistance: A Primer
نویسنده
چکیده
resistance of hiv to antiretroviral drugs is one of the most common causes for therapeutic failure in people infected with hiv. Sadly, the emergence of drug-resistant hiv variants is a common occurrence—even under the best of circumstances—given that no antiretroviral drug combination studied as of yet is completely effective in shutting down viral replication. And there is no shortage of data indicating that the emergence of hiv drug resistance is clearly associated with adverse treatment outcomes. Fortunately, the availability of drug-resistance testing has improved the ability of clinicians to deal knowledgeably with hiv drug resistance head on. On the research front, drug-resistance testing has enabled investigators to more effectively develop and study both novel and older therapeutics for the sake of tailoring treatment for patients with varying resistance profiles. In this respect, therapy can now be individualized, based on our evolving knowledge of drug resistance, drugresistance testing, and state-of-the-art treatment approaches. But if clinicians are to fully appreciate the epidemiology, prognostic tests, and various treatment choices related to hiv drug resistance, it is important to understand the mechanisms by which hiv drug resistance evolves. To explain this, and to illustrate some of the recent advances elucidating the mechanisms of hiv drug resistance, Dr. François Clavel took the podium at prn’s annual holiday dinner in December to provide a basic and not-so-basic overview.
منابع مشابه
Drug- Resistance- Associated Mutations and HIV Sub-Type Determination in Drug-Naïve and HIV-Positive Patients under Treatment with Antiretroviral Drugs
Abstract Background and Objective: Resistance to antiretroviral agents is a significant concern in clinical management of HIV-infected individuals. Resistance is the result of mutations that develops in the viral protein targeted by antiretroviral agents. Material and Methods: In this cross-sectional study, the blood samples of 40 HIV-positive patients were collected. Twenty of them were d...
متن کاملMechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase.
Human immunodeficiency virus (HIV) reverse transcriptase (RT) inhibitors can be classified into nucleoside and nonnucleoside RT inhibitors. Nucleoside RT inhibitors are converted to active triphosphate analogues and incorporated into the DNA in RT-catalyzed reactions. They act as chain terminators blocking DNA synthesis, since they lack the 3'-OH group required for the phosphodiester bond forma...
متن کاملDrug Resistance Profile and Subtyping of HIV-1 RT Gene in Iranian Patients under Treatment
Identification of drug resistant mutations is important in the management of HIV-1 infected patients. The aim of the current study was to evaluate drug resistance profile of RT gene and assess subtype among HIV-1 circulating strains and intensification of physician’s options for the best therapy. HIV-1 RNA of 25 sampleswas extracted from plasma and RT Nested- PCR was performed and the fin...
متن کاملSet up of Genotyping Test for Detection of HIV-1 Drug Resistance
Background and Aims: Genotyping assay has been accepted as a guidance in the therapeutic management of Human Immunodeficiency virus 1 (HIV-1). But, it is not commonly used in our country due to its high running cost. The aim of this study is evaluate an in-house genotyping resistance test (GRT) for HIV-1. Methods: HIV-1 RNA of 20 samples were extracted from plasma and RT Nested- PCR was perform...
متن کاملDrug-Resistant HIV-1 RT Gene Mutations in Patients under Treatment with Antiretroviral Drugs (HAART) in Iran
Abstract Background and Objective: Highly Active Antiretroviral Therapy (HAART) can effectively prevent the progression of HIV-1 replication and increase life expectancy. There are numerous causes of treatment failure and the leading one is drug resistance. Thus, we aimed to determine the HIV RT gene drug resistance mutations in patients treated with antiretroviral medications. Material...
متن کامل